Test CBC prior to initiating therapy, at weeks 2 and 4, more frequently if clinically warranted, and periodically thereafter.
Perform pregnancy test in women of childbearing potential prior to initiating treatment on a monthly basis during therapy and for 6 months after discontinuation.
Perform thyroid stimulating hormone test (TSH) prior to initiating therapy and periodically thereafter.
Perform renal function prior to initiation and periodically during therapy.
Perform eye exam at baseline in all patients and periodically during therapy.
Assess ECG in patients with preexisting heart disease prior to initiating therapy and periodically thereafter.