Ledipasvir/Sofosbuvir
성인

성인

1 tab = Ledipasvir 90 mg/Sofosbuvir 400 mg

  • Take with or without food

Genotype 1

Decompensated cirrhosis (Child-Pugh B or C)
  • BW <75 kg: 1 tab PO once daily x12w + Ribavirin 600 mg/d PO, titrated to 1,000 mg/d (2 divided doses)
  • BW ≥75 kg: 1 tab PO once daily x12w + Ribavirin 600 mg/d PO, titrated to 1,200 mg/d (2 divided doses)
Post-liver transplant, without cirrhosis or with compensated cirrhosis (Child-Pugh A)
  • BW <75 kg: 1 tab PO once daily x12w + Ribavirin 1,000 mg/d PO (2 divided doses)
  • BW ≥75 kg: 1 tab PO once daily x12w + Ribavirin 1,200 mg/d PO (2 divided doses)
Treatment-experienced, with compensated cirrhosis

1 tab PO once daily x24w (국내허가사항: 12주)

Treatment-experienced, without cirrhosis

1 tab PO once daily x12w

Treatment-naïve, without cirrhosis or with compensated cirrhosis

1 tab PO once daily x12w May consider x8w if HCV RNA level <6 million international units/mL

Genotype 4

Post-liver transplant, without cirrhosis or with compensated cirrhosis
  • BW <75 kg: 1 tab PO once daily x12w + Ribavirin 1,000 mg/d PO (2 divided doses)
  • BW ≥75 kg: 1 tab PO once daily x12w + Ribavirin 1,200 mg/d PO (2 divided doses)

Genotype 2, 4, 5, 6

Without cirrhosis or with compensated cirrhosis

1 tab PO once daily x12w