General Spectrum of Activity
Improvement in signs and symptoms of infection are indicative of efficacy.
Monitor patients with changing renal function; CrCl at least daily.
Consider monitoring renal function on elderly patients.
Antimicrobial Class: Cephalosporin, Penicillinase inhibitor
Pregnancy Category: B
Average serum half life: 1.9-4 hours (Ceftolozane), 0.7-3 hours (Tazobactam)
Urine penetration: Therapeutic
Lung penetration: Therapeutic
Decreased efficacy has been reported in patients with baseline creatinine clearance of 30-50 mL/min; monitoring recommended.
Infectious Diseases consult required for use (intensivists can order empirically in the ICU, if known MDR organism until ID can be consulted).
Should be reserved for patients with little or no other treatment alternatives.
Attribution: Antimicrobial information adapted from Sault Area Hospital