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항생제
Posaconazole

Posaconazole

제한된

N/A
N/A

Spectrum Of Activity

General Spectrum of Activity
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General Information

Prophylaxis of yeast and mould infections in certain immunosuppressed patients.

Monitor liver function tests, electrolyte disturbance, especially potassium, magnesium, and calcium.

Common

  • Hypokalemia
  • Diarrhea
  • Nausea
  • Vomiting
  • Headache
  • Fever

Serious

  • Prolonged QT interval
  • Torsades de pointes
  • Cholestasis (rare)
  • Liver failure (rare)

Contraindications:

  • Alkaloids (including ergotamine and dihydroergotamine)
  • HMG-CoA reductase inhibitors
  • CY3A4 substrates
  • Sirolimus
  • QT interval prolonging drugs

Multiple drug-drug interactions

Antimicrobial class: Antifungal, Triazole

Pregnancy category: C

Average serum half life: 22-66 hours

CSF penetration: Therapeutic

Precautions:

  • Electrolyte disturbances (K, Mg, and Ca) require monitoring and correction before and during therapy.
  • Monitoring recommended and discontinuation may be necessary in potentially serious or fatal hepatic reactions.
  • Avoid IV administration with moderate or severe renal impairment (GFR <50 mL/min/1.73 m(2)) unless benefit outweighs risk.

Attribution: Antimicrobial information adapted from Horizon Health Network