항생제
Rilpivirine

Rilpivirine

Spectrum Of Activity

General Information

Treatment of HIV infection.

Monitor viral load prior to initiation or modification of treatment.

Monitor CD4 cell counts prior to initiation or with modification of ARV treatment and every 3-6 months; thereafter during at least the first 2 years of treatment.

Monitor hepatitis B screening at baseline and with modification of ARV treatment.

Perform hepatitis C antibody testing prior to initiation or modification of ARV treatment.

Monitor ALT,AST, and total bilirubin at baseline and with modification of treatment.

Common

  • Rash
  • Raised cholesterol
  • Increased liver enzymes
  • Headache
  • Insomnia

Serious

  • Hypersensitivity reaction
  • Hepatotoxicity
  • Psychiatric effects
  • Membranous glomerulonephritis
  • Mesangial proliferative glomerulonephritis
  • CYP3A4 substrates
  • Proton pump inhibitors
  • QT prolonging drugs
  • Carbamazepine
  • Phenobarbital
  • Phenytoin
  • Rifampin
  • Oxcarbazepine
  • Dexamethasone
  • Rifapentine
  • Saquinavir
  • St. John’s Wort

Antimicrobial class: Antiretroviral, Non-nucleoside reverse transcriptase inhibitor

Pregnancy category: B

Average serum half life: 50 hours

Precautions: QT interval prolongation has been reported; use with caution with coadministration of other medications associated with an increased risk of torsade de pointes.

Monitoring recommended with underlying hepatic disease or marked elevations in baseline transaminases; consider monitoring in patients without preexisting hepatic impairment or other risk factors.

Discontinue immediately if signs or symptoms of severe skin and hypersensitivity reactions develop.

Depressive disorders have been reported; evaluate benefit and risk of continued treatment.