Raltegravir

Dosing

원내

HIV infection 1 film-coated tab (400 mg) PO q12h

If co-administrated with Rifampin, 800 mg PO q12hNo renal dose adjustmentChewable tablets and oral suspension are not interchangeable with film-coated tablets.

원내

Safety and efficacy in pediatric patients <4w of age have not been established

HIV infection

  • BW 3-4 kg: oral suspension 20 mg PO q12h

  • BW 4-6 kg: oral suspension 30 mg PO q12h

  • BW 6-8 kg: oral suspension 40 mg PO q12h

  • BW 8-11 kg: oral suspension 60 mg PO q12h

  • BW 11-14 kg: oral suspension 80 mg PO q12h

  • BW 14-20 kg: oral suspension 100 mg or 1 chewable tab (100 mg) PO q12h

  • BW 20-25 kg: 1.5 chewable tab PO q12h

  • BW >25 kg: 1 film-coated tab (400 mg) PO q12hNo renal dose adjustmentChewable tablets and oral suspension are not interchangeable with film-coated tablets.

Mild or moderate hepatic impairment No dose adjustment

Severe hepatic impairment No data

General Information

Treatment for HIV infection and used as part of a 3-drug combination regimen.

Monitor viral load prior to initiation or modification of treatment.

Monitor CD4 cell counts prior to initiation or with modification of ARV treatment and every 3-6 months; thereafter during at least the first 2 years of treatment.

Monitor hepatitis B screening at baseline and with modification of ARV treatment.

Perform hepatitis C antibody testing prior to initiation or modification of ARV treatment.

Monitor ALT,AST, and total bilirubin.

Monitor fasting blood glucose or HbA1c at baseline and with modification of ARV treatment.

Common

  • Nausea

  • Headache

  • Insomnia

  • Fatigue

Serious

  • Stevens-Johnson syndrome

  • Toxic epidermal necrolysis

  • Hypersensitivity

  • Rhabdomyolysis

  • Suicidal

  • Renal failure

  • Al or Mg antacids

  • Fosampernavir

  • Carbotegravir

  • Orlistat

  • Medications containing polyvalent cations

Antimicrobial class: Antiretroviral agent, Integrase Inhibitor

Pregnancy category: C

Average serum half life: 9 hours

Precautions: Discontinue use immediately if signs or symptoms of skin reactions develop.

Immune reconstitution syndrome has been reported; monitoring recommended; further evaluation and treatment of opportunistic infections may be necessary.

Chewable tablets contain phenylalanine.

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