Etravirine

Dosing

원내

HIV infection 200 mg PO q12hNo renal dose adjustment

원내

Safety and efficacy in pediatric patients <6 years of age or <16 kg of BW have not been established

HIV infection

  • BW: 16-20 kg: 100 mg PO q12h

  • BW: 20-25 kg: 125 mg PO q12h

  • BW: 25-30 kg: 150 mg PO q12h

  • BW: >30 kg: 200 mg PO q12hNo renal dose adjustment

Mild or moderate hepatic impairment No dose adjustment

Severe hepatic impairment No data

General Information

HIV infection, Treatment-experienced patients

Monitor viral load prior to initiation or modification of treatment.

Monitor CD4 cell counts prior to initiation or with modification of ARV treatment and every 3-6 months; thereafter during at least the first 2 years of treatment.

Monitor hepatitis B screening.

Perform hepatitis C antibody testing prior to initiation or modification of ARV treatment.

Monitor ALT,AST, and total bilirubin, basic chemistry including serum sodium, potassium, bicarbonate, chloride, BUN, creatinine, and creatinine-based estimated glomerular filtration rate.

Common

  • Rash

  • Diarrhea

  • Peripheral neuropathy

Serious

  • Myocardial infarction

  • Erythema multiforme

  • Stevens-Johnson syndrome

  • Toxic epidermal necrolysis

  • Hepatitis

  • Liver failure

  • Drug reaction with eosinophilia and systemic symptoms

  • Immune reconstitution syndrome

  • Rhabdomyolysis

Multiple drug-drug interactions

Contraindications:

  • Maroviroc

  • Dasabuvir

Antimicrobial class: Antiretroviral, Non-nucleoside reverse transcriptase inhibitor

Pregnancy category: B

Average serum half life: 9.05 - 41 hours

Urine penetration: Therapeutic

CSF penetration: Therapeutic

Precautions: Immune reconstitution syndrome has been reported with combination ARV therapy; patients whose immune system responds may develop an inflammatory response to indolent or residual opportunistic infections.

Discontinue immediately and monitoring recommended if hypersensitivity reactions or severe rash occurs.

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