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Cefotetan

Cefotetan

Spectrum Of Activity

General Spectrum of Activity
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General Information

  • Infection of bone
  • Infection of skin and/or subcutaneous tissue
  • Infectious disease of abdomen
  • Infectious disorder of joint
  • Lower respiratory tract infection
  • Pelvic inflammatory disease
  • Postoperative infection
  • Prophylaxis
  • Urinary tract infectious disease

Monitor renal function, electrolytes, CBC including platelets.

Common

  • Diarrhea
  • Nausea

Serious

  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Clostridium difficile colitis
  • Hemolytic anemia
  • Anaphylaxis
  • Seizure
  • Warfarin - increased risk of bleeding
  • Cholera vaccine, live
  • Typhoid vaccine, live

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 3-4.6 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Precautions:

  • Use with caution in patients with hypersensitivity to penicillins as cross-sensitivity may occur, and history of gastrointestinal disease.
  • Decrease in prothrombin activity and associated bleeding may occur, with increased risk in elderly and patients with renal or hepatobiliary impairment, poor nutritional status, and cancer.
  • Discontinue if Clostridium difficile associated diarrhea is suspected.
  • Monitoring recommended for overgrowth of nonsusceptible organisms and superinfection and hemolytic anemia.

Micromedex web. Greenwood Village (CO): Truven Health Analytics; 2019 [cited 2019 October 15]. Available from: Micromedex