Cefotetan

Dosing

Usual doseUTIMild or moderate SSTISevere SSTILife-threatening infectionSurgical prophylaxis1-2 g IV q12h0.5-1 g IV q12h1 g IV q12h2 g IV q12h3 g IV q12h1-2 g IV within 30-60 min prior to surgery

Safety and efficacy in pediatric patients have not been established

No dose adjustment

CrCl >30CrCl 10-30CrCl <10HDCRRTNo dose adjustmentRecommended dose IV q24hRecommended dose IV q48h1-2 g q48h (+ extra 1 g AD)

Non-HD days A quarter (1/4) of the usual dose

HD days Half of the usual dose750 mg q12h

General Information

  • Infection of bone

  • Infection of skin and/or subcutaneous tissue

  • Infectious disease of abdomen

  • Infectious disorder of joint

  • Lower respiratory tract infection

  • Pelvic inflammatory disease

  • Postoperative infection

  • Prophylaxis

  • Urinary tract infectious disease

Monitor renal function, electrolytes, CBC including platelets.

Common

  • Diarrhea

  • Nausea

Serious

  • Stevens-Johnson syndrome

  • Toxic epidermal necrolysis

  • Clostridium difficile colitis

  • Hemolytic anemia

  • Anaphylaxis

  • Seizure

  • Warfarin - increased risk of bleeding

  • Cholera vaccine, live

  • Typhoid vaccine, live

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 3-4.6 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Precautions:

  • Use with caution in patients with hypersensitivity to penicillins as cross-sensitivity may occur, and history of gastrointestinal disease.

  • Decrease in prothrombin activity and associated bleeding may occur, with increased risk in elderly and patients with renal or hepatobiliary impairment, poor nutritional status, and cancer.

  • Discontinue if Clostridium difficile associated diarrhea is suspected.

  • Monitoring recommended for overgrowth of nonsusceptible organisms and superinfection and hemolytic anemia.

Micromedex web. Greenwood Village (CO): Truven Health Analytics; 2019 [cited 2019 October 15]. Available from: Micromedex

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