Malaria: termination of acute malarial attack or absence of or reduced malarial parasite count on blood smear may indicate efficacy.
Systemic lupus erythematosus/rheumatoid arthritis: improvement in C-reactive protein levels and erythrocyte sedimentation rate may indicate efficacy.
Monitor renal and hepatic functions.
Monitor ECG, electrolytes, renal function, and hepatic function at baseline and during therapy.
Perform ophthalmologic examination in all patients beginning long-term therapy within the first year; repeat screening annually.