Minocycline

Dosing

Usual doseUncomplicated gonococcal urethritis in maleMeningococcal carrierC. trachomatis or U. urealyticum urethritis, endocervicitis, rectal infection100 mg IV/PO q12h100 mg IV/PO q12h x5d100 mg IV/PO x5d100 mg IV/PO q12hNo renal dose adjustment

Usual doseSafety and efficacy in pediatric patients ≤8 years of age have not been established2 mg/kg IV/PO q12hNo renal dose adjustment

No dose adjustment

General Information

Broad spectrum of activity.

Monitor creatinine BUN in patients with impaired renal function; serum magnesium levels; organ system function; Clostridioides difficle overgrowth; signs of thyroid ccancer.

Perform serologic syphilis testing upon diagnosis of gonorrhea with follow-up testing 3 months after treatment.

Ophthalmologic evaluations in patients reporting visual disturbances.

Common

  • Dizziness

  • Headache

  • Fatigue

Serious

  • Acidosis

  • Hyperphosphatemia

  • Clostridioides difficile infection

  • Enamel hypoplasia

  • Tooth discoloration

  • Hepatitis

  • Hepatic failure, acute

  • Anaphylaxis

  • Drug reaction with eosinophilia

  • Systemic lupus erythematosus

  • Arrest of bone development

  • Azotemia

  • Serum blood urea nitrogen raised

  • Pseudotumor cerebri

Contraindication:

  • Acitetin: increased risk of pseudotumor cerebri

Major drug-drug interactions:

  • Atazanavir

  • Penicillins

  • Digoxin

  • Methoxyflurane

  • Photosensitizing agents

  • Retinoids

  • Combination oral contraceptives

  • Cholera vaccine, live

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 16 hours

Attribution: Antimicrobial information adapted from Island Health

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