항생제
Atovaquone/Proguanil

Atovaquone/Proguanil

Spectrum Of Activity

General Information

  • Malaria, P. falciparum; Prophylaxis
  • Malaria, Uncomplicated, P. falciparum

Resolution in the signs and symptoms of acute, uncomplicated Plasmodium falciparum malaria is indicative of efficacy.

Monitor closely for parasitemia in patients who are vomiting.

Common

  • Pruritus
  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Abdominal pain
  • Loss of appetite
  • Increased liver function test
  • Asthenia
  • Dizziness
  • Headache

Serious

  • Neutropenia
  • Pancytopenia
  • Hepatitis
  • Liver failure

Major drug-drug interactions:

  • Efavirenz
  • Warfarin
  • Rifamycins
  • Dicumarol
  • Ritonavir
  • Sapropterin
  • Methotrexate
  • Carbamazepine
  • Cholera vaccine, live

Antimicrobial class: Quinone, Biguanide

Pregnancy category: C

Average serum half life: 2-3 days (adults), 1-2 days (pediatrics)

Precautions:

  • Relapse of Plasmodium vivax infection has commonly occurred in patients with mixed P. falciparum and Plasmodium vivax infections who were treated with monotherapy.
  • Use with caution for the treatment of malaria in patients with severe renal impairment (CrCl <30 mL/min) only if benefits outweigh potential risks.
  • Monitoring recommended in patients with vomiting or diarrhea; alternative therapy may be required.