Tetracycline

제한된
0
C. difficile 위험도
Low
경구생체이용률
Moderate

Dosing

Usual doseSevere infectionBrucellosisEarly syphilis in penicillin allergic patientsLate latent syphilis in penicillin allergic patientsGonorrheaUncomplicated C. trachomatis urethritis, endocervicitis, rectal infection500 mg PO q12h 250 mg PO q6h500 mg PO q6h500 mg PO q6h x3w + Streptomycin 1 g IM q12h x7d, then 1 g IM q24h x7d500 mg PO q6h x15d500 mg PO q6h x30d500 mg PO q6h x7d500 mg PO q6h x≥7d

Usual doseSafety and efficacy in pediatric patients ≤8y of age have not been established25-50 mg/kg PO #4

No dose adjustment

CrCl >50CrCl ≤50Recommended dose at recommended intervalsAvoid

General Information

Tetracycline has a broad spectrum of activity that includes Rickettsia, Chlamydia, Mycloplasma and many others.

Alternative therapy for early syphilis or gonorrhea in the penicillin-allergic patient.

Monitor fever, CBC, renal and hepatic function, and symptomatic improvement.

Common

  • Tooth discolored

Serious

  • Phototoxicity

  • Acidosis

  • Azotemia

  • Serum BUN raised

  • Bulging fontanelle

  • Pseudotumor cerebri

  • Raised intracranial pressure

Contraindications:

  • Methoxyflurane- may result in increased risk of nephrotoxicity

  • Acitretin - may result in increased risk of pseudotumor cerebri

Major drug-drug interactions:

  • Penicillins

  • Digoxin

  • Retinoids

  • Porfimer

  • Cholera vaccine, live

  • Combination oral contraceptives

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 6-12 hours

CSF penetration: Poor

Attribution: Antimicrobial information adapted from Vitalité Health Network

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