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항생제
Rifabutin

Rifabutin

Spectrum Of Activity

General Spectrum of Activity
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General Information

Disseminated infection due to Mycobacterium avium-intracellulare group; Prophylaxis- HIV infection

Increase monitoring in patients with underlying liver disease.

Obtain acid-fast bacilli smear and culture until 2 consecutive culture specimens are negative.

Perform chest x-rays after 2-3 months of treatment and at end of treatment.

Monitor for signs or symptoms of hypersensitivity reaction or uveitis.

Common

  • Rash
  • Clostridium difficile diarrhea
  • Loss of taste
  • Ocular discoloration
  • Uveitis
  • Discolored urine

Serious

  • Neutropenia
  • Thrombocytopenia
  • Systemic lupus erythematosus

Contraindications:

  • Voriconazole
  • CYP3A4 inducers
  • Artemether/Lumefantrine
  • Ranolazine

Multiple drug-drug interactions

Antimicrobial class: Antitubercular, Rifamycin

Pregnancy category: B

Average serum half life: 45 hours

Precautions:

  • In patients with severe renal impairment (CrCl <30 mL/min), dose reduction recommended if toxicity is suspected and monitoring recommended.
  • Not recommended in patients with known active TB; may lead to TB that is resistant to rifabutin and rifampin.
  • Uveitis may occur; monitoring recommended during concurrent use of macrolide antibiotic or fluconazole and and related compounds; interruption may be necessary.
  • Discontinue use if Clostridioides difficile-associated diarrhea or hypersensitivity reaction is suspected.