Cefoperazone

Dosing

Usual doseSevere infection1-2 g IV q12h6-12 g IV #3-4 (max 4 g/dose)No renal dose adjustment

목동병원에서만 사용함

Safety and efficacy in pediatric patients have not been established

목동병원에서만 사용함

No dose adjustment

General Information

  • Endometritis

  • Female genital infection

  • Gonorrhea

  • Infection of skin and/or subcutaneous tissue

  • Infectious disease of abdomen

  • Pelvic inflammatory disease

  • Peritonitis

  • Urinary tract infectious disease

  • Respiratory tract infection

Monitor fever, symptomatic improvement, CBC, and hepatic and renal functions.

Check previous hypersensitivity to other beta-lactam antibiotics.

Monitor prothrombin time in patients at risk.

Monitor signs of antibiotic-associated diarrhea, serum-sickness-like reactions, and thrombophlebitis.

Common

  • Injection site phlebitis/pain

  • Diarrhea

Serious

  • Erythroderma

  • Stevens-Johnson syndrome

  • Toxic epidermal necrolysis

  • Gastrointestinal hemorrhage

  • Vitamin K deficiency

  • Hypersensitivity reaction

  • Disulfiram-like reaction

  • Warfarin, Heparin - increased risk of bleeding

  • Cholera vaccine, live

  • Typhoid vaccine, live

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic

Precautions:

  • Exercise with caution in patients with history of GI disease, especially colitis.

  • Monitor for vitamin K deficiency.

  • Hepatic impairment and comorbid significant renal disease requires monitoring if high dosages are used.

  • Use cautiously in beta-lactam allergy patients.

  • Discontinue if allergic reaction occurs.

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