Spectrum Of Activity
First line anti-tuberculosis drug.
Active tuberculosis, HIV infection.
HIV infection, inactive tuberculosis.
Obtain acid-fast bacilli smear and culture from sputum until 2 consecutive culture specimens are negative.
Perform chest x-rays after 2-3 months of treatment and at end of treatment.
Monitor hepatic function, signs and symptoms of hypersensitivity reactions and signs of treatment-associated side effects.
Perform ophthalmic examinations if visual symptoms occur.
Increased liver enzymes
Systemic lupus erythematosus
Monitor when used in combination with drugs at risk of liver damage such as Benzodiazepines and Acetaminophen. Directly observed therapy (DOT) advised for treatment of active TB.
Major drug-drug interactions:
Antimicrobial class: Antitubercular, Isonicotinic Acid
Pregnancy category: C
Average serum half life: 0.7-4 hours
CSF penetration: Therapeutic
Tyramine and histamine containing foods should be avoided during use.
Careful monitoring recommended for HIV seropositive patients; treatment interruption or discontinuation may be required.
Careful monitoring recommended for patients with preexisting peripheral neuropathy or conditions predisposing to neuropathy; treatment interruption or discontinuation may be required.
Discontinue use for recurrent hypersensitivity reactions.