항생제
Nafcillin

Nafcillin

Medium
N/A

Spectrum Of Activity

General Information

Treatment of MSSA infections

Infective endocarditis, Oxacillin-susceptible staphylococci

Staphylococcal infectious disease, penicillinase-producing staphylococci

Monitor baseline and periodic CBC with differential.

Monitor liver and renal functions.

  • Phlebitis at injection site
  • C. difficile colitis
  • Hypokalemia
  • Agranulocytosis
  • Bone marrow depression
  • Tubulointerstitial nephritis
  • Abnormal liver enzymes
  • CYP3A/4 inducers
  • Warfarin- decreased PT/INR
  • Cyclosporine- decreases serum concentrations
  • Tetracyclines

Antimicrobial class: Antistaphylococcal penicillin

Pregnancy category: B

Average serum half life: 0.5-1 hr

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Route of Elimination: Primarily hepatic

Precautions:

  • Use caution in patients with concomitant hepatic insufficiency and renal dysfunction, sensitivity to allergens or history of asthma.
  • Discontinuation of Clostridium difficile associated diarrhea may be necessary.

Attribution: Antimicrobial information adapted from Dignity Health (Bakersfield Hospital)