Imipenem/Cilastatin
신기능 저하

신기능 저하

CrCl >70

500 mg IV q6h

CrCl 41-70

500 mg IV q8h

CrCl 21-40

250 mg IV q6h

CrCl 6-20

250 mg IV q12h

CrCl ≤5

Avoid

HD

200 mg q6h OR 500 mg q 12h (administer AD and at intervals times from end of that HD session)

  • When normal dose is 500 mg q6h: 200 mg IV q6h
  • When normal dose is 1000 mg q6-8h: 500 mg IV q12h
CRRT

500-1000 mg q12h

CAVH or CVVH

500 mg (or 50% usual dose) q6-8h