이화여자대학교 의료원 logo
항생제
Cefditoren

Cefditoren

Spectrum Of Activity

General Spectrum of Activity
​

General Information

  • Acute bacterial exacerbation of chronic bronchitis
  • Community-acquired pneumonia
  • Infection of skin and/or subcutaneous tissue
  • Pharyngitis
  • Tonsillitis

Monitor culture/sensitivity when appropriate, white count with differential, and temperature.

Perform liver and renal function tests.

Monitor signs of toxicity (e.g. diarrhea, nausea, rash, vaginal discharge).

Common

  • Diarrhea
  • Nausea
  • Candida vaginitis

Serious

  • Erythema multiforme
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Clostridium difficile colitis
  • Hypersensitivity reaction
  • Acute renal failure
  • Interstitial pneumonia
  • Pulmonary eosinophilia
  • Probenecid: result in increased cefditoren pivoxil serum concentrations and bioavailability
  • Famotidine: result in decreased cefditoren serum concentrations
  • Cefditoren and antacids: result in decreased cefditoren effectiveness
  • Cholera vaccine, live
  • Oral contraceptives

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1.6 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic

Precautions:

  • Use caution in patients who have had previous hypersensitivity reactions to penicillins.
  • Not recommended if long-term therapy is indicated due to risk of developing carnitine deficiency; increased risk in patients with renal impairment or decreased muscle mass.
  • Prothrombin activity decreases may be associated with cephalosporin use, especially in patients with renal or hepatic impairment, poor nutritional state, prolonged course of antimicrobial therapy, or previously stabilized on anticoagulants; monitoring recommended.
  • If pseudomembranous colitis is diagnosed, discontinue therapy and treat with appropriate measures.