Spectrum Of Activity
CAPAECBPharyngitis, tonsillitisUncomplicated SSTI400 mg PO q12h x14d400 mg PO q12h x10d200 mg PO q12h x10d200 mg PO q12h x10d
CAPAECBPharyngitis, tonsillitisUncomplicated SSTISafety and efficacy in pediatric patients <12y of age have not been established400 mg PO q12h x14d400 mg PO q12h x10d200 mg PO q12h x10d200 mg PO q12h x10d
Mild or moderate hepatic impairmentSevere hepatic impairmentNo dose adjustmentNo data
CrCl >50CrCl 30-49CrCl 10-30CrCl <10HDCRRTNo dose adjustment200 mg PO q12h200 mg PO q24hNo data200 mg q24h (give after hemodialysis on dialysis days)No data
Acute bacterial exacerbation of chronic bronchitis
Infection of skin and/or subcutaneous tissue
Monitor culture/sensitivity when appropriate, white count with differential, and temperature.
Perform liver and renal function tests.
Monitor signs of toxicity (e.g. diarrhea, nausea, rash, vaginal discharge).
Toxic epidermal necrolysis
Clostridium difficile colitis
Acute renal failure
Probenecid: result in increased cefditoren pivoxil serum concentrations and bioavailability
Famotidine: result in decreased cefditoren serum concentrations
Cefditoren and antacids: result in decreased cefditoren effectiveness
Cholera vaccine, live
Antimicrobial class: 3rd Generation Cephalosporin
Pregnancy category: B
Average serum half life: 1.6 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
Biliary penetration: Therapeutic
Use caution in patients who have had previous hypersensitivity reactions to penicillins.
Not recommended if long-term therapy is indicated due to risk of developing carnitine deficiency; increased risk in patients with renal impairment or decreased muscle mass.
Prothrombin activity decreases may be associated with cephalosporin use, especially in patients with renal or hepatic impairment, poor nutritional state, prolonged course of antimicrobial therapy, or previously stabilized on anticoagulants; monitoring recommended.
If pseudomembranous colitis is diagnosed, discontinue therapy and treat with appropriate measures.