항생제
Gemifloxacin

Gemifloxacin

High
Excellent

Spectrum Of Activity

General Information

  • A fluoroquinolone bactericidal drug with a wide-spectrum of activity against Gram-negative and Gram-positive microorganisms
  • Acute bacterial exacerbation of chronic bronchitis
  • Community-acquired pneumonia

Black Box Warning:

  • Fluoroquinolones are associated with disabling and potentially irreversible serious adverse reactions.
  • Reserve use of gemifloxacin mesylate for patients with no alternative treatment options for acute bacterial exacerbation of chronic bronchitis.
  • Avoid in patients with known history of myasthenia gravis.

Monitor fever, CBC, symptomatic improvement.

Common

  • Rash
  • Abdominal pain
  • Diarrhea
  • Nausea
  • Vomiting
  • Headache
  • Dizziness

Serious

  • Aortic aneurysm
  • Prolonged QT interval
  • Hypoglycemia
  • Myasthenia gravis
  • Rupture of tendon
  • Tendinitis
  • Neurological symptoms
  • Psychiatric symptoms

Contraindication:

  • QT interval prolonging drugs

Multiple drug-drug interactions

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7 hours

Precautions:

  • Increased risk of QT interval prolongation in patients with ongoing proarrhythmic conditions.
  • Discotninue if hypersensitivity reactions, neurologic effects, and toxic psychosis occur.
  • Discontinue therapy at first sign of tendon pain, swelling, inflammation, or rupture.
  • Sensory or sensorimotor axonal polyneuropathy that may be irreversible has been reported; discontinue if symptoms occur.