Ethambutol

Dosing

15-20 mg/kg PO q24h (max 16 g)

10-15 mg/kg PO q24h

CrCl >80CrCl 50-80CrCl 10-50CrCl <10HDCAPD15-20 mg/kg PO q24h15 mg/kg PO q24h15 mg/kg PO q24-36h15 mg/kg PO q48h 15 mg/kg PO after HD15 mg/kg PO q24h

General Information

Pulmonary tuberculosis, adjunct.

First-line anti-tuberculous agent.

Obtain acid-fast bacilli smear and culture from sputum at least monthly until 2 consecutive culture specimens are negative.

Perform chest x-rays after 2-3 months of treatment and at end of treatment.

Obtain follow-up smears frequently until 2 consecutive specimens are negative.

Perform liver and renal function tests at baseline and periodically.

Perform visual acuity tests at baseline and periodically; monthly for patients receiving doses greater than 15 mg/kg/day.

Serious

  • Hepatotoxicity

  • Anaphylaxis

  • Hypersensitivity reaction

  • Optic neuritis

  • Aluminum-containing antacids - separate by at least 4 hours

  • Delamanid

  • BCG vaccine, live

Antimicrobial class: Antitubercular

Pregnancy category: C

Average serum half life: 2.5-4 hours

Urine penetration: Therapeutic

CSF penetration: Poor

Precautions:

  • Decreased in visual acuity, possibly to optic neuritis; may be related to dose and treatment duration; close monitoring recommended.

  • Monitoring recommended for liver toxicities.

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