Obtain acid-fast bacilli smear and culture from sputum at least monthly until 2 consecutive culture specimens are negative.
Perform chest x-rays after 2-3 months of treatment and at end of treatment.
Obtain follow-up smears frequently until 2 consecutive specimens are negative.
Perform liver and renal function tests at baseline and periodically.
Perform visual acuity tests at baseline and periodically; monthly for patients receiving doses greater than 15 mg/kg/day.