Spectrum Of Activity
Pulmonary tuberculosis, adjunct.
First-line anti-tuberculous agent.
Obtain acid-fast bacilli smear and culture from sputum at least monthly until 2 consecutive culture specimens are negative.
Perform chest x-rays after 2-3 months of treatment and at end of treatment.
Obtain follow-up smears frequently until 2 consecutive specimens are negative.
Perform liver and renal function tests at baseline and periodically.
Perform visual acuity tests at baseline and periodically; monthly for patients receiving doses greater than 15 mg/kg/day.
Aluminum-containing antacids - separate by at least 4 hours
BCG vaccine, live
Antimicrobial class: Antitubercular
Pregnancy category: C
Average serum half life: 2.5-4 hours
Urine penetration: Therapeutic
CSF penetration: Poor
Decreased in visual acuity, possibly to optic neuritis; may be related to dose and treatment duration; close monitoring recommended.
Monitoring recommended for liver toxicities.