Empiric therapy of bacterial meningitis
Empiric therapy of nosocomial Gram negative infections (except Pseudomonas)
Calcium containing IV solutions bind to ceftriaxone forming an insoluble precipitate- avoid concurrent use with calcium contaning colutions in neonates.
IM ceftriaxone may be given with 1% lidocaine to minimize pain at injection site
Antimicrobial class: Parenteral Cephalosporin - 3rd Generation
Average serum half life: • Neonates: 1-4 days: 16 hours; 9-30 days: 9 hours
Route of Elimination: unchanged in the urine (33-67%) by glomerular filtration and in feces via bile.