Piperacillin/Tazobactam Neonatal Dosing

Piperacillin/Tazobactam Neonatal Dosing


Doses are based on the piperacillin component


  • Infuse over 20 to 30 minutes
  • Aminoglycoside antibiotics (amikacin, gentamicin, tobramycin) may be inactivated by piperacillin/tazobactam when infused through the same IV line right after piperacillin/tazobactam
  • For all first doses of piperacillin/tazobactam and aminoglycosides administer the antibiotics one right after another using the following procedure:

    • Administer piperacillin/tazobactam first
    • Flush manually at the medication port with 3mL of NS. If you have a PICC, you must use a pump (attach the NS pre-filled sterile syringe to the medication port and press the "volume over time" feature. Set it for 3mL over 5 minutes)
    • Administer the aminoglycoside
  • For all subsequent doses, schedule the administration times so that the antibiotics are given 1 hour apart from each other

  • NOTE: Piperacillin/tazobactam and aminoglycosides can be administered at the same time without flushing or separation of administration times when each drug is infused through a separate PIV line or through different lumens of a double or triple lumen catheter