Penicillin (Includes Penicillin G and Penicillin VK)

Penicillin (Includes Penicillin G and Penicillin VK)


General Information

Pregnancy: Compatible.

Breastfeeding: Compatible.

Pencillin G (IV): Therapy of Streptococcal and other documented susceptible infections (including invasive Group A Streptoccus infections), neurosyphilis, intrapartum Group B Streptococcus prophylaxis.

Penicillin VK: Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract, urinary tract infections), prophylaxis after rheumatic fever

  • Monitor for allergic reaction
  • Periodic CBC, SCr
  • Allergy/rash (immediate or delayed)
  • Seizures (IV therapy, high doses)
  • Cytopenias
  • Eosinophilia
  • Interstitial nephritis
  • Abnormal liver enzymes
  • Serum sickness
  • Positive Coombs

No significant drug interactions.

For patients reporting allergies to penicillins: take an allergy history, refer to the allergy management section on this site including the penicillin and beta lactam allergy management tool and cross reactivity table. Call Antimicrobial Stewardship for assistance.

Antimicrobial class: Penicillin