General Information

Pregnancy: Limited published data in human pregnancies, however, due to the known safety of other beta lactams, meropenem is considered compatible in pregnancy.

Breastfeeding: Meropenem transfers into breastmilk in very small amounts and is not well absorbed orally. Two case reports published did not show any adverse events in two infants exposed to meropenem via breastmilk. Meropenem is given in therapeutic doses to infants. It is considered compatible with breastfeeding. Monitor the infant for any signs of gastrointestinal intolerance.

Therapy of serious infections involving multi-drug resistant gram negative organisms.

  • Scr

  • Liver enzymes

  • CBC if therapy prolonged

  • Immediate and delayed-type allergy
  • GI disturbance, cytopenias, positive Coombs
  • Liver enzyme abnormalities

Valproic acid - carbapenems decrease valproate levels and may decrease seizure threshold

Antimicrobial class: Carbapenem