General Spectrum of Activity
Pregnancy and Lactation
Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC > =2) and VRE including endovascular infections.
Do NOT use for the treatment of pneumonia.
Creatine kinase weekly.
Statins and fibrates: monitor creatine kinase or hold while on daptomycin therapy (increased myopathy)
Higher doses used for endovascular infection.
Inactivated by pulmonary surfactant and therefore should not be used for pulmonary infections.
Antimicrobial class: Cyclic lipopeptide, depolarizes bacterial cell membrane