General Information


  • Compatible.
  • Consider alternative to ceftriaxone (ie. cefotaxime) at the time of delivery (particularly in preterm delivery) to minimize exposure to newborn.


  • Compatible.
  • Empiric therapy of bacterial meningitis.
  • Empiric therapy of nosocomial Gram negative infections (except Pseudomonas).
  • Empiric therapy of hospitalized community or nursing home acquired pneumonia.
  • Empiric therapy of spontaneous bacterial peritonitis.
  • Empiric treatment of pyelonephritis.
  • Gonorrhea (in combination with azithromycin).
  • Allergy/rash (immediate or delayed)
  • Cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities
  • Pseudocholelithiasis - unclear clinical significance - uncommonly symptomatic, but frequently found by ultrasound gallbladder sludge

Ceftriaxone should not be diluted or administered simultaneously with any calcium-containing solution via a Y-site in any patient. However, ceftriaxone and calcium-containing solutions may be administered sequentially of one another for use in patients other than neonates if infusion lines are thoroughly flushed (with a compatible fluid) between infusions.

Fatal lung and kidney damage associated with calcium-ceftriaxone precipitates has been observed in premature and term neonates. Due to reports of precipitation reaction in neonates, do not reconstitute, admix, or coadminister with calcium-containing solutions, even via separate infusion lines/sites or at different times in any neonate.

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation