• Empiric therapy of bacterial meningitis.
• Empiric therapy of nosocomial Gram negative infections (except Pseudomonas).
• Empiric therapy of hospitalized community or nursing home acquired pneumonia.
• Empiric therapy of spontaneous bacterial peritonitis.
• Empiric treatment of pyelonephritis.
• Gonorrhea (in combination with azithromycin).

• Allergy/rash (immediate or delayed)
• Cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities
• Pseudocholelithiasis - unclear clinical significance - uncommonly symptomatic, but frequently found by ultrasound gallbladder sludge

Ceftriaxone should not be diluted or administered simultaneously with any calcium-containing solution via a Y-site in any patient. However, ceftriaxone and calcium-containing solutions may be administered sequentially of one another for use in patients other than neonates if infusion lines are thoroughly flushed (with a compatible fluid) between infusions.

Fatal lung and kidney damage associated with calcium-ceftriaxone precipitates has been observed in premature and term neonates. Due to reports of precipitation reaction in neonates, do not reconstitute, admix, or coadminister with calcium-containing solutions, even via separate infusion lines/sites or at different times in any neonate.