Lipid associated AmB is taken up preferentially by phagocytic cells and concentrated at sites of infection while minimizing renal exposure.
Adequate hydration prior to infusion is recommended to reduce risk of nephrotoxicity.
- K and Mg supplementation may be required.
Premedication with analgesics, antiemetics, antihistamines and hydrocortisone may be required for infusion related reactions. These reactions are usually more common with the first few doses and generally diminish with subsequent doses.