General Information

Pregnancy: Amoxicillin/clavulanic acid may be associated with NEC in the newborn if given near delivery in the setting of PPROM

Breastfeeding: Compatible

  • Prophylaxis/treatment of bite wounds
  • Polymicrobial infections of the respiratory tract or abdomen
  • Skin and soft tissue infections

For prolonged therapy monitor liver enzymes, CBC

  • Gastrointestinal side effects - diarrhea
  • Hepatotoxicity due to clavulanate - usually mild, liver failure is rare
  • Allergy/rash (immediate or delayed), cytopenias
    • Note EBV related rash
  • Contraindicated in patients with true penicillin allergies.
  • Amoxicillin shares a common structural side chain with cephalexin, therefore, there is an increased risk of allergy cross reactivity between this agents.
    • Please see penicillin and beta lactam allergy management tool and cross reactivity table.

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor