Spectrum of Activity

General Information


  • Compatible in all stages of pregnancy, no untoward effects reported


  • Compatible

Therapy and prophylaxis for herpes viral infections

Follow SCr as appropriate, check urine for crystals if suspect AKI

  • GI upset, phlebitis - common
  • Increased SCr
  • AKI from crystal nephropathy

May diminish efficacy of varicella vaccine.

People taking long-term antiviral therapy should discontinue these drugs, if possible, at least 24 hours before administration of varicella vaccine and should not restart antiviral therapy until 14 days after vaccination.

Oral: 200 mg tablets IV: 500 mg vials

For oral indications, consider valacyclovir (pro-drug) which is more bioavailable with more convenient dosing.

Keep well hydrated to prevent nephrotoxicity from crystallization in renal tubules.

Dosage adjustment required in renal impairment, consult pharmacy.

Use adjusted body weight for calculating IV doses in obese patients.

Antimicrobial class: Antiviral, nucleoside analogue