Flucytosine (5-FC)

Flucytosine (5-FC)


Good (70 to 90%)

General Information


  • Enterocolitis
  • Nausea/vomiting
  • Diarrhea
  • Hepatotoxicity
  • Bone marrow toxicity when serum flycytosine level is greater than 100 mg/L
  • Do not use as a single antifungal agent. Resistance develops quickly when used as monotherapy.
  • Well absorbed after oral administration and distributes widely, with good penetration into CSF, vitreous and peritoneal fluids

Data from adult studies unless otherwise noted

Oral bioavailability: 78 to 89% (decreased in neonates)

Plasma Protein Binding: 3 to 4%

Elimination: Eliminated primarily as unchanged drug by the kidneys by glomerular filtration. Increase dosing interval in neonates with impaired renal function and monitor trough serum flucytosine levels closely