Long acting benzathine penicillin G is the appropriate treatment for syphilis. It achieves detectable serum levels of penicillin for 2 - 4 weeks and is required to adequately treat infectious syphilis. Short acting penicillin G does not provide adequate treatment for syphilis (except neurosyphilis).
Pregnant individuals with syphilis with a penicillin allergy should undergo desensitization.
Do not inject near an artery or a nerve; permanent neurological damage or gangrene may result. When doses are repeated, rotate the injection site. Do not administer IV, intra-arterially, or SubQ.