Piperacillin-Tazobactam
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis: Standard (EGFR)

0 - 20 eGFR

2.25g IV q8h

20 - 40 eGFR

3.375g IV q8h

40+ eGFR

3.375g IV q6h

Not On Dialysis: Pneumonia (EGFR)

0 - 20 eGFR

2.25g IV q6h

20 - 40 eGFR

3.375g IV q6h

40+ eGFR

4.5g IV q6h

Intermittent Dialysis

2.25g IV q8h, 0.75g IV after dialysis

Continuous Dialysis

4.5g IV q6h