Severe Beta-Lactam Allergy
Beta hemolytic streptococci
S. aureus
Cephalexin 25 mg/kg PO TID
Max: 1000mg
PLUS
Mupirocin topical
Linezolid 10 mg/kg IV
Max: 600mg
≥ 2 serotonergic agents: Monitor for signs of serotonin syndrome and consider switching to another option
De-escalate to narrowest spectrum PO antibiotic based on susceptibilities
Duration: 7 days
Penicillin Allergy Assessment