Antimicrobials
Aztreonam

Aztreonam

Restricted

Medium
N/A
$$$$$

Spectrum of Activity

General Information

  • Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent
  • Nebulized form used in cystic fibrosis patients
  • Renal and liver function
  • CBC
  • Elevated liver enzymes
  • Cytopenias
  • Eosinophilia
  • Phlebitis at injection site
  • Rash/allergy
  • CNS toxicity
  • Hypotension
  • Seizures
  • Increased SCr

Use with caution in patients with congenital or acquired arginase deficiency or other conditions where tolerance to L-Arginine may be limited

Antimicrobial class: Monobactam

Average serum half life:

  • Neonates:
    • <7 days, ≤2.5 kg: 5.5 to 9.9 hours
    • <7 days, >2.5 kg: 2.6 hours
    • 1 week to 1 month: 2.4 hours
  • Children 2 months to 12 years: 1.7 hours
  • Children with cystic fibrosis: 1.3 hours

Route of Elimination:

  • 60% to 70% excreted unchanged in the urine by active tubular secretion and glomerular filtration
  • 12% excreted in feces