Antimicrobials
Amphotericin B - lipid associated

Amphotericin B - lipid associated

Restricted

Low
N/A

Dosing

General Information

Infectious Diseases consultation recommended.

CBC, K, HCO3, Mg, liver profile.

Same toxicities as conventional Amphotericin B but with less frequency.

Infusion related symptoms are common: fever/rigors/N/V/headache. They usually diminish with subsequent doses.

Electrolyte abnormalities - hypoK and hypoMg, renal tubular acidosis.

Nephrotoxicity

Main concern is concomitant nephrotoxins - use should be minimized during amphotericin therapy.

Digoxin - increased digoxin toxicity with hypokalemia.

Careful attention to electrolyte and fluid status with boluses (usually 500 mL) of NS before and after infusion, as well as K and Mg supplementation as needed.

Antimicrobial class: Antifungal - polyene - Lipid formulations (designed to minimize toxicity)

Pregnancy category: B