Antimicrobials
Azithromycin

Azithromycin

Medium
Moderate

Spectrum of Activity

Dosing

General Information

Community acquired pneumonia, Pertussis, upper respiratory tract infections, Chlamydial infections, mycobacterial infections, Mycobacterium avium complex (MAC) prophylaxis in HIV patients.

Monitor QTc in patients with increased risk

Prolongation of QTc interval - Association with increased cardiovascular mortality in observational studies.

Prolonged half life may contribute to macrolide resistance.

Other drugs that prolong QTc

Increases cyclosporine levels

May increase digoxin levels

Statins increased risk of rhabdomyolysis

Increases INR with warfarin

Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing - i.e. Salmonella spp

May exacerbate muscle weakness in persons with myasthenia gravis. Use with caution.

Antimicrobial class: Macrolide

Pregnancy category: B