Non-invasive gram-positive infections (e.g., skin and soft tissue infections):

• 4-6 mg/kg IV q24h

Bacteremia and invasive infections:

• Staphylococci (including methicillin-resistant) and Enterococci: 6-10 mg/kg IV q24h
• Vancomycin-resistant enterococci (VRE): 8-10 mg/kg IV q24h; 12 mg/kg IV q24h may be required for highly resistant strains

Endocarditis:

• Methicillin-resistant staphylococci: 8-10 mg/kg IV q24h
• Resistant enterococci (including VRE): 10-12 mg/kg IV q24h