Antimicrobials
Daptomycin

Daptomycin

Restricted

Low
N/A

Dosing

General Information

Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC>=2) and VRE including endovascular infection.

Creatine kinase weekly.

Myopathy including rhabdomyolysis, GI side effects common, rash, phlebitis, increased INR.

Statins and fibrates: monitor creatine kinase or hold while on daptomycin therapy (increased myopathy).

Infectious Disease consultation recommended.

Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.

Antimicrobial class: Cyclic lipopeptide, depolarizes bacterial cell membrane

Pregnancy category: B