Amphotericin B - conventional

Amphotericin B - conventional



General Information

Infectious Diseases consultation recommended.

CBC, K, HCO3, Mg, liver profile.

Infusion related symptoms are common: fever/rigors/N/V/headache. They usually diminish with subsequent doses.

Electrolyte abnormalities - hypoK and hypoMg, renal tubular acidosis


Main concern is concomitant nephrotoxins - use should be minimized during amphotericin therapy

Digoxin - increased digoxin toxicity with hypokalemia

Careful attention to electrolyte and fluid status with boluses (usually 500 mL) of NS before and after infusion, as well as K and Mg supplementation as needed.

If high risk of renal toxicity, consider liposomal amphotericin B formulation.

Antimicrobial class: Antifungal - polyene

Pregnancy category: B