Antimicrobials
Voriconazole

Voriconazole

Restricted

Low
Excellent

Dosing

General Information

Infectious Diseases consultation recommended for use.

Therapeutic drug monitoring may be helpful to ensure adequate concentrations and exclude toxicity.

QTc interval in patients at elevated risk

Monitor hepatic profile

Creatinine, electrolytes (K+, Mag+, Ca+)

  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash - up to 20%
  • Visual disturbance
  •  Fluorosis
  • GI upset

CYP450 interactions ++

Other QTc prolonging agents

Voriconazole increases concentration of phenytoin. Phenytoin decreases concentration of voriconazole. Drug monitoring recommended.

Recommend review of patient medications due to high frequency of significant interactions.

Food may decrease oral absorption. Should be taken 1hr before or 1 hr after a meal.

Avoid/limit use of IV formulation in renal failure due to accumulation of vehicle (cyclodextrin).

Antimicrobial class: Triazole antifungal

Pregnancy category: D