Antimicrobials
Linezolid

Linezolid

Restricted

Low
Excellent

Spectrum of Activity

Dosing

General Information

Restricted to infections caused by gram positive organisms that are resistant to vancomycin or in patients intolerant to vancomycin.

CBC at least once/week

Visual testing for therapy >3mo or if symptoms develop on therapy

Myelosuppression (usually after 2 weeks therapy) - reversible

Peripheral/optic neuropathy with prolonged courses

Serotonin syndrome

Rash

Elevated liver enzymes

Lactic acidosis

SSRI and other serotonergics/MAOIs - increased risk of serotonin syndrome

Rifampin decreases linezolid levels

Antimicrobial class: Oxazolidinone

Pregnancy category: C