Antimicrobials
Tigecycline

Tigecycline

Medium
N/A

Spectrum of Activity

Dosing

General Information

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility

Associated with more treatment failures than alternatives and excess mortality - Black Box Warning

Avoid or use with caution in patients with tetracycline reactions

GI side effects very prominent with significant nausea and vomiting

Tetracycline related adverse events: photosensitivity, acute pancreatitis

Rash, abnormal liver enzymes

Oral contraceptives less effective

Requires Infectious Disease consultation

Documented safety concerns in bacteremia

An increase in all-cause mortality has been observed in a meta-analysis of phase 3 and 4 clinical trials in tigecycline-treated patients versus comparator.

Antimicrobial class: Tetracycline derivative

Pregnancy category: D

Average serum half life: 42.0

Lung penetration: Therapeutic

Biliary penetration: Therapeutic