Antimicrobials
Moxifloxacin

Moxifloxacin

High
Excellent

Spectrum of Activity

Dosing

General Information

Monitor QTc in patients with increased risk

  •  QTc prolongation
  • Dysglycemia
  • CNS toxicity including confusion, psychosis
  • Tendinopathy and rupture
  • GI upset
  • Weakness exacerbation in myasthenia gravis
  • Rash

QTc prolongation - Increased risk with other agents that prolong QTc

Divalent cations including Ca, Mg - decreased absorption

Warfarin - increased INR

Rifampin - decrease moxifloxacin levels

Low urinary drug levels - do not use to treat UTI.

May exacerbate muscle weakness in persons with myasthenia gravis. Avoid Use.

Antimicrobial class: Fluoroquinolone

Pregnancy category: C