Antimicrobials
Metronidazole

Metronidazole

Low
Excellent

Dosing

General Information

With prolonged therapy (>6wks) or if symptoms develop assess for peripheral/optic neuropathy

GI symptoms common- especially nausea/vomiting and metallic taste

Peripheral/optic neuropathy with extended therapy

Disulfiram-like reaction with alcohol (severe vomiting)

Rare neurotoxicity including aseptic meningitis and encephalopathy

Ethanol- disulfiram-like reaction

Increases levels of cyclosporine, lithium, warfarin, and phenobarbital and phenytoin

Antimicrobial class: Nitroimidazole

Pregnancy category: B