Prosthetic valve endocarditis or prosthetic joint infections caused by Staphylococci in combination with other agents (cefazolin, nafcillin, vancomycin, etc)
Inducer of CYP 2B6, 2C8, 2C9, 2C19 and p-glycoprotein
Commonly seen interactions in the hospital: amiodarone, atorvastatine (change to rosuvastatin), digoxin, azole antifungals, warfarin, thyroid medication, etc. Contact pharmacist for further details.
Inductive effects typically take 1-2 weeks to reach steady state. Typically resolve 1-2 weeks after discontinuation of therapy