Antimicrobials
Rifampin

Rifampin

Low
Excellent
PO: $1/day IV: $75/day

Dosing

General Information

  •  Tuberculosis
  •  Nontuberculosis Mycobacterial infections (NTM)
  •  Prosthetic valve endocarditis or prosthetic joint infections caused by Staphylococci in combination with other agents (cefazolin, nafcillin, vancomycin, etc)
  •  Discoloration (reddish-orange) of body fluids
  •  Hepatitis
  •  GI intolerance
  •  Flu-like syndrome

LOTS!

  •  Potent inducer of CYP3A4
  •  Inducer of CYP 2B6, 2C8, 2C9, 2C19 and p-glycoprotein
  •  Commonly seen interactions in the hospital: amiodarone, atorvastatine (change to rosuvastatin), digoxin, azole antifungals, warfarin, thyroid medication, etc. Contact pharmacist for further details.
  •  Inductive effects typically take 1-2 weeks to reach steady state. Typically resolve 1-2 weeks after discontinuation of therapy
  •  Check drug drug interactions upon stopping and starting rifampin
  •  Food reduces absorption. If possible take on empty stomach.

Antimicrobial class: Rifamycin

Pregnancy category: C

Average serum half life: 2-5 hours

Route of Elimination: Hepatic