Antimicrobials
Aztreonam

Aztreonam

Restricted

Medium
N/A
$150-200/day

Spectrum of Activity

Dosing

General Information

Therapy of gram negative infections including Pseudomonas, particularly in patients with Penicillin and Cephalosporin anaphylaxis or when there is no alternative susceptible agent.

Specialized nebulized form used in Cystic fibrosis patients (do not use IV formulation for nebulization).

Empiric therapy for Febrile neutropenia in patients with severe Penicillin and Cephalosporin allergy - must give in combination with Vancomycin (for the gram-positive coverage).

Monitor liver enzymes and renal function

  •  Elevated liver enzymes
  •  Cytopenias
  •  Eosinophilia
  •  Phlebitis at injection site
  •  Rash/allergy
  •  CNS toxicity

No significant interactions.

Restricted to infectious diseases providers. Verify allergies and reactions to specific agents with patient before calling.

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic