General Spectrum of Activity
In addition to other agents for necrotizing fascitis or toxic shock syndrome.
Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.
For decreasing toxin production in toxic shock syndrome.
Anaerobic infections above the diaphragm, especially dental infection.
Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta-lactam for reducing toxin production.
Skin & soft tissue infections involving susceptible MRSA.
Monitor for diarrhea.
Muscle relaxants, e.g., Atracurium, Baclofen, Diazepam.
St. Johns Wort
Not a great empiric drug for coverage of MRSA based on local susceptibility profiles.
High risk for C. difficile infection.
Antimicrobial class: Lincosamide
Pregnancy category: B
Average serum half life: 2.4 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Poor
No renal adjustment required