C difficile risk
Oral Bioavailability
$11 to $16 per day


CrCl < 10CrCl 10 - 29CrCl 30 - 601g IV q24hHigh dose 2g IV q24h Standard dose 1g IV q24hHigh dose: 2g IV q12h Standard dose: 2g q24h

1g IV q24h, ensure scheduled after HD on HD days

Alternative option: dose ONLY post HD: 2,2,3g post-HD TIW

2 g loading dose followed by 1-2g IV q12h

High dose (Pseudomonas, meningitis, obesity)Standard dose2 g IV q8h2 g IV q12h

2 g IV q6h

150 mg/kg/day divided q8h

100 mg/kg/day divided q12h

150 to 200 mg/kg/dose q6-8h

Max 2 g q6h

General Information

  • Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas

  • Neutropenic fever

  • Used especially for nosocomial infections involving resistant organisms

Long term: CBC, BMP weekly

  • Allergy (immediate & delayed)

  •  Positive Coombs

  •  Cytopenias

  •  Non-convulsive status epilepticus

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate

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