Antimicrobials
Ciprofloxacin

Ciprofloxacin

High
Excellent
Oral: <$1/day IV: $4-7/day

Spectrum of Activity

Dosing

General Information

Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites

Monitor QTc in patients with increased risk

  • QTc prolongation
  • Aortic dissection
  • Aortic Aneurysm
  • Dysglycemia
  • Tendinopathy and rupture
  • GI upset
  • Rash
  • Retinal detachment
  • CNS toxicity including confusion, psychosis
  • Weakness exacerbation in myasthenia gravis
  • MULTIPLE BLACK BOX WARNINGS BY FDA
  • CYP1A2 inhibitor - Multiple interactions possible
  • QTc prolongation - Increased risk with other agents that prolong QTc
  • Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption
  • Cyclosporine - Increased levels of cyclosporine
  • Warfarin - Increased INR
  • Methadone - Lowered seizure threshold

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic