Antimicrobials
Daptomycin

Daptomycin

Restricted

Low
N/A
$20-40/day

Spectrum of Activity

Dosing

General Information

Targeted therapy of resistant gram positive infections with MRSA and VRE including endovascular infection.

Creatine kinase weekly

  • GI side effects common
  • Rash
  • Phlebitis
  • Increased INR
  • Myopathy including rhabdomyolysis
  • Eosinophilic pneumonitis

Statins and fibrates - Increased myopathy. Monitor creatine kinase while on daptomycin therapy.

Higher doses used for endovascular infection.

Recommend Infectious Diseases Consult.

Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.

Antimicrobial class: Cyclic Lipopeptide.

Pregnancy category: B

Average serum half life: 9 hours

CSF penetration: Possible - case reports

Lung penetration: Poor

Urine penetration: Therapeutic